Discussions

Prominent nucleoli​ are often observed in cells with high metabolic activity or rapid growth, such as cancer cells. The nucleolus is the site of ribosomal RNA (rRNA) synthesis and ribosome biogenesis, making its size and prominence a marker of protein synthesis capacity within the cell. In pathology, prominent nucleoli can serve as a diagnostic indicator of malignancy in various cancers, as they reflect increased cellular proliferation and metabolic demands. Understanding the role of prominent nucleoli​ in tumor biology can aid in the development of targeted therapies that disrupt protein synthesis and inhibit tumor growth.